Full Name: Ying-Qian Liu 

Position: Professor 

E-mail: yqliu@lzu.edu.cn 

Address: School of Pharmacy, Lanzhou University, Lanzhou, Gansu, 730000, China

Education:

Sep. 2002-Jul. 2007 

Ph.D. degree at Lanzhou University, Major in organic chemistry

Professional Background:

Jan. 2014~present 

Professor,School of Pharmacy, Lanzhou University 

Jan. 2010~Jul. 2014 

Associate Professor, School of Pharmacy, Lanzhou University 

Aug. 2007-Jul. 2010 

Lecturer, School of Pharmacy, Lanzhou University

Courses:

Organic chemistry (for undergraduate students); Introduction to organic synthesis (for graduate students)

Textbook:

  < Organic chemistry >, People’s Medical Publishing House, Jun. 2022

Research experience

  Ying-Qian Liu is a Professor, and doctoral supervisor in theSchool of Pharmacy of Lanzhou University. He isappointed as the "Flying Scholar" of Gansu Province, “Long Yuan Young Innovative Talent” of Gansu Province, responsible for the Industry Technology Center in Gansu Province of the development and utilization of effective substances in Chinese and Tibetan Medicine, and the director of natural medicine Chemical Biology Institute. Currently, he is appointed as the vice chairman of the Ethnic Medicine Education Committee of China Ethnic Medicine Association, the member of the first Expert Committee of the Chinese Medicine and Agricultural Industry Branch of the World Union, the director of the China Biomedicine Integration Alliance, the vice chairman of the Aromatic Medicine Branch of the Chinese Ethnic Medicine Association, and the vice chairman of the Strategic Alliance of Technological Innovation of Gansu Provincial Hospital Preparation Industry, the director of Gansu Provincial Chemical Society, the chairman of Medicinal Chemistry of Gansu Provincial Chemical Society and the chairman of natural medicine and pharmaceutical industry economy of Gansu Provincial Pharmaceutical Society.

In recent years, with "natural medicinal chemical biology" as the main research direction, the research group has systematically carried out the lead discovery, diversity-oriented synthesis, efficacy evaluation and application development research based on traditional Chinese medicine and natural biological active functional molecules. His achievements have published more than 80 high-level SCI papers such as Med. Res. Rev., J. Med. Chem., Europ. J. Med. Chem., etc. He was invited to publish the Top journal Med. Res. Rev. on the theme of "Chinese Medicine and Medicinal Plant Resources in the West and the Belt and Road". He has written a series of thematic reviews and participated in the editing of three books as an associate editor. More than 100 national invention patents and one PCT patent have been applied, and five achievements have been transformed. Responsible for and participate in research projects: more than 30 scientific and technological projects such as the National Key Research and Development Program of China, the National Natural Science Foundation, the key research and development Program of Gansu Province, and the Key Program for international S&T cooperation projects of China Gansu Province, and more than 50 horizontal projects of cooperation with enterprises and joint industry-university-research projects with enterprises.

Research Interests 

The main research direction of the research group: natural medicinal chemical biology, its main focus: 1) Lead discovery, design, synthesis and application development of antitumor agents; 2) Lead discovery, design, synthesis and application development of antimicrobial agents.

Honor and Awards: 

Pharmaceutical Star of Western China;

the First Prize of Pharmaceutical Development awarded by Gansu Pharmaceutical Society;

the Second Prize of Pharmaceutical Development awarded by Gansu Pharmaceutical Society;

the Science and Technology Award of China Association of Chinese Medicine;

the Third Prize of Science and Technology Progress awarded by Nanjing City.

Representative Publications:

[1] Mei-Juan Wang, Ying-Qian Liu,* Ling-Chu Chang, Chih-Ya Wang, Yong-Long Zhao, Xiao-Bo Zhao, Keduo Qian, Xiang Nan, Liu Yang, Xiao-Ming Yang, Hsin-Yi Hung, Jai-Sing Yang, Daih-Huang Kuo, Masuo Goto, Susan L. Morris-Natschke, Shiow-Lin Pan, Che-Ming Teng, Sheng-Chu Kuo, Tian-Shung Wu, Yang-Chang Wu, Kuo-Hsiung Lee*. Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents. J. Med. Chem. 2014, 57, 6008～6018.

[2] Liang Kou, Mei-Juan Wang, Li-Ting Wang, Xiao-Bo Zhao, Xiang Nan, Liu Yang, Ying-Qian Liu*, Susan L. Morris-Natschke, Kuo-Hsiung Lee*. Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions. Europ. J. Med. Chem. 2014, 75, 282～288.

[3] Xiao-Bo Zhao, Masuo Goto, Zi-Long Song, Susan L. Morris-Natschke, Yu Zhao, Dan Wu, Liu Yang, Shu-Gang Li, Ying-Qian Liu*, Gao-Xiang Zhu, Xiao-Bing Wu, Kuo-Hsiung Lee*. Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents. Bioorg. Med. Chem. Lett. 2014, 24, 3850～3853.

[4] Xiao-Bo Zhao, Dan Wu, Mei-Juan Wang, Masuo Goto, Susan L. Morris-Natschke, Ying-Qian Liu*, Xiao-Bing Wu, Zi-Long Song, Gao-Xiang Zhu, Kuo-Hsiung Lee*. Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents. Bioorg. Med. Chem. Lett. 2014, 22, 6453～6458.

[5] Ying-Qian Liu, Wen-Qun Li, Susan L. Morris-Natschke, Keduo Qian, Liu Yang, Gao-Xiang Zhu, Xiao-Bing Wu, An-Liang Chen, Shao-Yong Zhang, Xiang Nan, Kuo-Hsiung Lee*. Perspectives on Biologically Active Camptothecin Derivatives. Med. Res. Rev. 2015, 35, 753-789.

[6] Zi-Long Song, Hai-Le Chen, Yu-Han Wang, Masuo Goto, Wen-Jing Gao, Pi-Le Cheng, Susan L. Morris-Natschke, Ying-Qian Liu*, Gao-Xiang Zhu, Mei-Juan Wang, Kuo-Hsiung Lee*. Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction. Bioorg. Med. Chem. Lett. 2015, 25, 2690～2693.

[7] Ying-Qian Liu, Jing Tian, Keduo Qian, Xiao-Bo Zhao, Susan L. Morris-Natschke, Liu Yang, Xiang Nan, Xuan Tian,  Kuo-Hsiung Lee*. Recent Progress on C-4-Modified Podophyllotoxin Analogs as Potent Antitumor Agents. Med. Res. Rev. 2015, 35, 1～62.

[8] Zi-Long Song, Mei-Juan Wang, Lanlan Li, Dan Wu, Yu-Han Wang, Li-Ting Yan, Susan L. Morris-Natschke, Ying-Qian Liu*, Yong-Long Zhao, Chih-Ya Wang, Huan-xiang Liu*, Masuo Goto, Heng Liu, Gao-Xiang Zhu, Kuo-Hsiung Lee*. Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives. Europ. J. Med. Chem. 2016, 115, 109～120.

[9] Cheng-Jie Yang, Zi-Long Song, Masuo Goto, Pei-Ling Hsu, Xiao-Shuai Zhang, Qian-Ru Yang, Ying-Qian Liu*, Mei-Juan Wang, Susan L. Morris-Natschke, Xiao-Fei Shang, Kuo-Hsiung Lee*. Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives. Bioorg. Med. Chem. Lett. 2017, 27, 4694～4697.

[10] Cheng-Jie Yang, Zi-Long Song, Masuo Goto, Ying-Qian Liu*, Kan-Yen Hsieh, Susan L. Morris-Natschke, Yong-Long Zhao, Jun-Xiang Zhang, Kuo-Hsiung Lee*. Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties. Bioorg. Med. Chem. Lett. 2017, 27, 3959～3962.

[11] Gao-Xiang Zhu, Pi-Le Cheng, Masuo Goto, Na Zhang, Susan L. Morris-Natschke, Kan-Yen Hsieh,Guan-Zhou Yang, Qian-Ru Yang, Ying-Qian Liu*, Hai-Le Chen, Xiao-Shuai Zhang, Kuo-Hsiung Lee*. Design, synthesis and potent cytotoxic activity of novel 7-( N -[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives. Bioorg. Med. Chem. Lett. 2017, 27, 1750～1753.

[12] Xiao-Fei Shang, Susan L. Morris-Natschke, Guan-Zhou Yang, Ying-Qian Liu*, Xiao Guo, Xiao-Shan Xu, Masuo Goto, Jun-Cai Li, Ji-Yu Zhang, Kuo-Hsiung Lee*. Biologically active quinoline and quinazoline alkaloids part II. Med. Res. Rev. 2018, 38, 1614～1660.

[13] Xiao-Fei Shang, Susan L., Morris-Natschke, Ying-Qian Liu*, Xiao Guo, Xiao-Shan Xu, Masuo Goto, Jun-Cai Li, Guan-Zhou Yang, Kuo-Hsiung Lee*. Biologically active quinoline and quinazoline alkaloids part I. Med. Res.Rev. 2018, 38, 775～828.

[14] Jun-cai Li, Ren-xuan Wang, Yu Sun, Jia-kai Zhu, Guan-fang Hu, Yu-ling Wang, Rui Zhou, Zhong-min Zhao, Ying-qian Liua*, Jing-wen Peng, Yin-fang Yan, Xiao-fei Shang. Design, synthesis and antifungal activity evaluation of isocryptolepine derivatives. Bioorg. Chem. 2019, 92, 103266.

[15] Xiao-Fei Shang, Li-Xia Dai, Ying-Qian Liu*, Zhong-Min Zhao, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Acaricidal activity and enzyme inhibitory activity of active compounds of essential oils against Psoroptes cuniculi. Vet. Parasitol. 2019, 267, 54～59.

[16] Guan-Zhou Yang, Jia-Kai Zhu, Xiao-Dan Yin, Yin-Fang Yan, Yu-Ling Wang, Xiao-Fei Shang, Ying-Qian Liu*, Zhong-Min Zhao, Jing-Wen Peng, Hua Liu. Design, synthesis, and antifungal evaluation of novel quinoline derivatives inspired from natural quinine alkaloids. J. Agric. Food Chem. 2019, 67, 11340～11353.

[17] Xiao-Fei Shang, Cheng-Jie Yang, Susan L. Morris-Natschke, Jun-Cai Li, Xiao-Dan Yin, Ying-Qian Liu*, Xiao Guo, Jing-Wen Peng, Masuo Goto, Ji-Yu Zhang, Ku-Hsiung Lee*. Biologically active isoquinoline alkaloids covering 2014–2018. Medicinal Research Reviews, 2020, 40, 1～78.

[18] Cheng-Jie Yang, Bin Li, Zhi-Jun Zhang, Jian-Mei Gao, Mei-Juan Wang, Xiao-Bo Zhao, Zi-Long Song, Ying-Qian Liu*, Hu Li, Yu-yuan Chen, Kuo-Hsiung Lee, Susan L. Morris-Natschke, Chuan-rui Xu. Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin. Europ. J. Med. Chem. 2020, 187, 111971.

[19] Yu-YuanChen,Yin-Peng Bai, Bin Li, Xiao-BoZhao,Cheng-JieYang,Ying-Qian Liu*,Jian-MeiGao,JunGuo,Chun Li,Jing-WenPeng,Zhong-MinZhao,Zhi-JunZhang,Chuan-RuiXu*. Design and synthesis of novel 20(S)-α-aminophosphonate derivatives of camptothecin as potent antitumor agents. Bioorg. Chem. 2021,114, 105065.

[20] Junmin Zhang, Susan L. Morris-Natschke, Di Ma, Xiao-Fei Shang,  Chen-Jie Yang, Ying-Qian Liu*, Kuo-Hsiung Lee*. Biologically active indolizidine alkaloids. Med Res Rev. 2021, 41, 928～960.